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遺伝毒性発がん物質の閾値：頂上征服への一途上
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福島昭治・鰐渕英機・森村圭一朗・魏 民
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大阪市立大学大学院医学研究科都市環境病理学
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Are there thresholds for carcinogenicity on genotoxic carcinogens?
Shoji FUKUSHIMA Hideki WANIBUCHI Keiichirou MORIMURA and Min WEI
Department of Pathology Osaka City University Medical School Osaka 545-8585 Japan
Abstract: Until recently it has been generally considered that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However the non-threshold theory can be challenged with regard to assessment of cancer risk to humans. In the present study we show that food-related genotoxic hepatocarcinogens heterocyclic amines and N-nitroso compounds at low doses do not induce preneoplastic lesions and cancer-related markers in rat medium-term carcinogenicity bioassay. The results imply existence of a threshold at least practical one for carcinogenicity of genotoxic carcinogens.
(ChemoBio Integrated Management 1(1):10-17 2005)
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| Keywords: |
genotoxic carcinogens , cancer risk assessment , carcinogenicity threshold , heterocyclic amines , N-nitroso compounds , |
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[PDF (186.3K)]
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第1巻 , 創刊号 , (pp.10-17)
